About Helicobacter pylori

What is Helicobacter pylori?

Helicobacter pylori is a type of tiny Gram-negative bacterium. It has a spiral shape and flagella, which allows it to move around in the gastric mucosa. The adhesive molecules on its surface can bind to receptors on the surface of gastric mucosal cells, helping them to attach to the gastric mucosa and avoid being washed away. These characteristics enable Helicobacter pylori to survive and colonize in the stomach environment, leading to infections and related stomach problems.

Infection with Helicobacter pylori

Infection with Helicobacter pylori can lead to varied responses among different individuals. Some individuals may not exhibit noticeable symptoms even if they are infected with Helicobacter pylori. Others might experience an overproduction of stomach acid due to the infection, leading to complications like antral gastritis and duodenal ulcers. Yet another group of individuals who contract Helicobacter pylori may develop chronic gastritis, further elevating the risk of developing gastric cancer.

Nearly half of the global population is estimated to be infected with H. pylori

The primary modes of transmission for Helicobacter pylori infection are through diet and oral contact. This bacterium can be present in the saliva, oral cavity, vomit, or feces of infected individuals. It can spread through direct contact, sharing utensils, consuming contaminated food or water, and more. Additionally, infection can occur through contact with the vomit or feces of an infected person.

Ref：
1.JGH Open, Volume: 7, Issue: 1, Pages: 3-15, First published: 21 November 2022, DOI: (10.1002/jgh3.12843)
2. Ali Pormohammad, J Cell Physiol, 2019;234:1208–1218

Diagnose for Helicobacter pylori Infection

Invasive / Non-invasive	Invasive	Non-invasive
Invasive / Non-invasive
Test method	Gastroscopy	Stool Antigen Test	Serologic test	¹³C Urea breath test	Instant-UBTIW
Sample type	Stomach tissue	Fecal	Blood	Exhale breath	Exhale breath
Time	1-2 hr	3-7 days	3-7 days	3-7 days	<1 hr
Cost	High	Low	Low	Medium	Medium
Advantage/ Disadvantage	Uncomfortable	Available before and after teatment	Not Available after treatment.Does not distinguish between active and past infection	Available before and after teatment	Available before and after teatment
Accuracy	High	Low	Low	High	High

UltraPeace-Instant
Helicobacter pylori urea breath test kit

Detection Principle

When the stomach is infected with Helicobacter pylori. The orally given urea is hydrolysed by the enzyme urease of H. pylori and carbon dioxide and ammonia gas is expired in breath . By analyzing the concentration of ammonia gas expired through breath and comparing it with the baseline value before drinking urea. It can help to determine the presence of Helicobacter pylori infection.

Core Patent Technology

Disposable Gas pH Electrochemical Test Strip

Utilizing patented developed nanoporous hydrogel membrane to capture ammonia gas from exhaled breath, the gas undergoes hydrolysis on the electrode surface. Through electrochemical detection, the pH value of the gas is obtained, enabling the calculation of ammonia gas concentration in the exhaled breath.